Samuel H. Sloan, Bs. D.

AIDS is said to be incurable. Yet, thousands have been HIV positive for more than ten years and are still in perfect health. Many AIDS cures are being tested experimentally around the world. Yet, the average AIDS suffer is being denied access to these drugs.

Almost certainly, the cure for AIDS already exists in a laboratory somewhere. Yet, it will still take years for even the most promising AIDS treatments to reach the market place, by which time you will already be dead.

The author has taken the results of the latest AIDS research from the most impenetrable scientific journals and has broken them down into simple language which even the layman can understand. Topics include: How the "intelligent" AIDS virus works, the battle over accelerated approval, how AZT can and will kill you, aggressive treatment for HIV infection, the implications of AIDS for the development of therapies and vaccines, HIV disease: new tools for understanding, mother-to-child HIV transmission and food-based nutrients as therapeutic options in HIV care.

The author also reports dozens of interviews of AIDS sufferers, from whom he learned their thus-far successful methods for keeping themselves alive until a cure for HIV finally becomes available to everyone.

Finally, in view of the fact that knowledge of AIDS is rapidly progressing and improving, the author explains how to keep up to date on the latest scientific developments towards a universal AIDS cure, so that the information in this book will not become obsolete.

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Dear Richard, November 18, 1994

The enclosed proposed book has already been written, for all practical purposes. All I have to do it take the latest scientific journals, of which there are many available here in San Francisco, and break them down into simple language of not more than five letters per word each.

I have already obtained the journals I need to write this book. I have also spoken to a large number of HIV positive individuals who will give me free advice on this project.

I could list the book immediately in Forthcoming Books in Print.

One journal I have here is called: BETA, the Bulletin of Experimental Treatments for AIDS, September 1994, published by the San Francisco AIDS Foundation. It is 88 pages long, 8 1/2 x 11 and small type. All I have to do is rewrite it into simple language (as it is highly technical) and we have a more than 200 page book.

It will take me two to three weeks to write this book.

All I need is assurances that it will get to the printer, and I will start writing the book right away.



Chapter One

How the HIV Virus Works

by Samuel H. Sloan

The HIV virus has often been characterized as "intelligent", because of its ability to adapt to changing conditions. It seems that every time the HIV virus is attacked by an effective anti-biotic, it mutates to a form which is resistant to that attack.

However, researchers now understand that this is not really what happens. Rather, when the HIV virus first enters its host, it replicates itself trillions of times, to such an extent that within a very short period of time, about 25 % of all of the cells within the bloodstream are infected with this virus.

Why then does not the virus kill its host quickly, rather than take years to complete its work?

The answer is that as soon as vast numbers of the HIV virus are manufactured, the body's immune system goes to work and quickly kills almost all of the examples of the virus.

"Almost all" is the key phrase here. Although the HIV virus replicates itself trillions of times, the copies are not exact. Just as a photocopy machine always produces a copy almost exactly like but at the same time always slightly different from the last one, the HIV virus makes copies which are each a little different from the others. When the body's immune system develops anti-bodies to kill the virus, the fact that there are trillions of different kinds of copies means that there are always a few versions which it can't quite kill.

This is the reason that HIV seems to go through a remission stage, where it has no effect. Actually, there is a constant war being waged inside the bloodstream. The few remaining copies of the HIV virus keep trying to increase their numbers, while being quickly killed by the body's anti-bodies. This situation remains in relative balance for a long time, often years.

In fact, the HIV virus never actually wins the war. What happens is that the body's immune system gradually becomes weakened by this constant war against HIV, to the point where other entirely different viruses, which would otherwise usually be harmless, are able to invade and eventually to kill the host. These are called "opportunistic" viruses.

The next question is: Why can't we just manufacture a drug which will kill HIV in much the same way that so many other viruses are killed?

The answer is that after some time, HIV actually imbeds itself in the DNA of the bloodstream. Its genetic code becomes part of the host in such a way that it is inseparable from it. It is no longer a foreign object floating around in the blood, ready to be harpooned like a whale or swatted like a fly. Instead, it is really part of the person.

The HIV virus contains RNA. RNA stands for ribonucleic acid. All cells of any kind contain RNA. HIV RNA contains the genetic code of the HIV virus. After HIV infects human cells, its genetic information, as found in its RNA, is transcribed into the DNA of the human host. As a result, the HIV RNA takes over the machinery of its human host cell. The host cell is then instructed by the RNA to replicate itself, producing new virus particles. These virus particles then spread to infect new blood cells in the human host.

This is the reason why researchers now say that the only way completely to kill the HIV virus is to attack it at the very beginning, when it first invades its human host and before it becomes imbedded in the DNA. Once the HIV RNA becomes part of the human DNA, there is no known way to kill it. Instead, the objective then becomes just a holding action, to try to keep the human host alive for as long as possible.

As Benjamin Franklin once said, the only two things certain in life are death and taxes. We will all die, eventually. One of our primary objectives in the game of life is therefore simply to stay alive as long as possible. Thousands of HIV positive individuals are now playing this same game, only against greater odds. If they can keep themselves alive for 50 years or more, until the natural ravages of old age set in, they will have effectively countered this disease, even though they may not have cured it.

However, by doing so, they also assure the perpetuity of the disease. It is now known that the human race has existed for about three million years. We only know the history of the last few thousand years, and our knowledge of events dating back even that far is confined to a few isolated events. We simply don't know how many diseases there have been which have wiped out vast segments of the human population, before the advent of recorded history. We now know less than 0.1% of the history of the human race.

One thing is different now, however. A disease which struck five thousand or more years ago, at the most wiped out the entire tribe infected by it and perhaps a few neighboring tribes confined to a relatively small locality. Now, however, with modern transportation and communication, a disease which strikes a remote Indian tribe in the Amazon jungle could, within a few weeks, turn up in central China or among the Australian Aborigines. In short, a disease could now strike which would quickly kill the entire human race, just as the dinosaurs were suddenly exterminated 65 million years ago.

Such a possibility has not existed previously. This is not a remote or far-fetched possibility. In fact, the laws of probability tell us that this will happen eventually. We can only hope that it will happen long after we are gone.

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